Ozwell E. Spencer

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First appearance: Resident Evil 1

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Leader of Umbrella. Descended from European nobility, Spencer was one of the discoverers of the progenitor virus, a new type of RNA virus, along with James Marcus and Edward Ashford. He suggested that the other two should join with him and create a company to develop biological weapons based on their virus research. The three of them formed a dummy corporation called the Umbrella Corporation.


Spencer built the Arklay Laboratory in Raccoon Forest the same year that the progenitor virus was discovered, in order to advance his virus research in complete secrecy. He asked the renowned architect George Trevor to design the laboratory so that it would look like a mansion from the outside. Trevor was killed under suspicious circumstances shortly after the construction was completed. According to Trevor's wife, Jessica, and daughter, Lisa, he was used as a human test subject for the progenitor virus in order to keep his mouth shut. Then, by promoting the ill-at-ease Professor Marcus to head of the executive training school, gradually Spencer was able to increase his strength within the company.


The research that was being conducted at Arklay Lab at the time was none other than the T-Virus project, which later Research triggered the Mansion Incident. This project was competing with the independent research being done by Professor Marcus at the Executive Training School. The turning point in the project was the success of the experiments with mutated leeches. When Spencer learned of this, he brought Albert Wesker and William Birkin, who were both executive candidates at the time, over to his side and had Professor Marcus assassinated. They then stole all of Marcus's T-Virus research. In this way, Spencer managed to perfect the T-Virus through William, and at the same time took full control of Umbrella.